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lncRNAs can affect the biological property of tumor cells at the cellular function level by affecting intracellular transduction pathways, such as cell proliferation, drug resistance, immune evasion and apoptosis ( 8, 9). Over the past ten years, mounting investigations have focalized long non-coding RNAs (lncRNA), a sort of small molecules of >200 nucleotide units without protein-coding functions, which enact a crucial part in the stride of CRC ( 6, 7).

While optimizing the strategies of combined radiotherapy and chemotherapy and targeted therapy and immunotherapy, researchers are also trying to hunt for splendid therapeutic targets to ameliorate the survival and prognosis of CRC cases. Nevertheless, the five-year and ten-year survival rate of CRC patientss is unsatisfactory as before ( 5). With the development of medicine, various treatment options, for instance, radiotherapy, chemotherapy, biological targeted therapy and molecular biological therapy have been adopted in CRC therapy ( 2- 4).

According to 2021 cancer statistics, the annual incidence and mortality of CRC worldwide was ranked second and third in the world, respectively ( 1).

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Begg's funnel plot test using the Stata 12.0 software suggested that no significant heterogeneity was found.Ĭonclusion: Elevated lncRNA SNHGs expression was revealed to be positively correlated to discontented CRC clinical outcome and lncRNA SNHG may act as a potential clinical prognostic index for CRC patients.Ĭolorectal cancer (CRC) seriously threatens human life and health, well-being and happiness quotient. Additionally, high lncRNA SNHGs expression was inclined to later TNM stage (OR=1.635, 95% CI: 1.405–1.864, P<0.001), distant lymph node invasion, distant organ metastasis, larger tumor diameter and poor pathological grade. High lncSNHG expression means bad survival prognosis in CRC patients (HR=1.635, 95% CI: 1.405–1.864, P<0.001). Elevated lncRNA SNHGs expression was revealed in colorectal tumor tissues. Results: 25 eligible publications including 2,342 patients were finally included to appraise the association of lncRNA SNHGs with prognosis of CRC. Detailed downstream signaling pathways of lncRNA SNHGs were summarized in detail We pooled the hazard ratios (HR) with 95% confidence interval (CI) through direct or indirect collection of effect sizes, and odds ratios (OR) with 95% CI by collecting effect sizes within articles. The quality of published papers was evaluated in details. Methods: Systematic searches were performed from the six relevant databases from inception to October 20, 2022. This research indented to screen whether exist potential prognostic effect of lncRNA SNHGs in CRC patientss using comprehensive review and meta-analysis.

However, no research has systematically evaluated the correlation among lncRNA SNHGs expression and survival outcome of CRC. Introduction: Growing evidence shows that long non-coding RNA small nucleolar RNA host genes (lncRNA SNHGs) enact an pivotal regulatory roles in the shorter survival outcome of colorectal cancer (CRC).

2Colorectal Surgery Department, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

1Department of Gastroenterology, Qian Xi Nan Buyi and Miao Autonomous Prefecture People's Hospital, Xingyi, Guizhou, China.

Pei Luo 1*, Jie Du 2, Yinan Li 2, Jilong Ma 2 and Wenjun Shi 2

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